Combinatorial Chemistry By Nicholas K. Terrett (PB)
Editorial Reviews
"Terrett's timely book discusses the practical and economic advantages of the combinatorial approach in the synthesis of libraries of compounds used in drug discovery. Combinatorial chemistry made its debut in 1991, using the discovery of the Merrifield polypeptide synthesis (1963) as a starting point. The combinatorial method is employed in making pure compounds and mixtures in the search for biological activity. Because of its rapidity, low cost, and the potential to generate large numbers of diverse compounds, the combinatorial approach is used extensively by pharmaceutical companies. This technology has provided previously unknown leads that can be followed up by the synthesis of single compounds, which optimize the efficacy of the lead structures. . . . Excellent illustrations supplement the discussions. Other features include chapter references, a brief index, and a most welcome table of abbreviations. Upper-division undergraduates through professionals."--Choice